Perturbation of Lipid and Protein Structure by General Anesthetics: How Little Is Too Little?

population (e.g., to very young patients, where, in fact, the predicted risk can be exaggerated using our model). However, the scope of our current investigation did not include pediatric cases. The increase in the incidence of PONV among pediatric patients and the decrease in the incidence of PONV with increasing adult age means that the association is not linear if we combine pediatric and adult patients. It does not mean that a bimodal distribution exists between PONV and age, in which there should be two peaks in the distribution. There is one peak (i.e., one mode) in late childhood, with a lower incidence of PONV in early childhood and adulthood. We have developed and validated a mathematical model to calculate the risk of PONV among ambulatory surgical patients. We believe that this model will predict patients’ risk of PONV and promote efforts to reduce the incidence of PONV.